¿Es efectiva la terapia administrada vía internet para la depresión?: Una Revisión Sistemática (Is Online Therapy Effective for Depression? A Systematic Review)

¿Es efectiva la terapia administrada vía internet para la depresión?: Una Revisión Sistemática (Is Online Therapy Effective for Depression? A Systematic Review)

Contenido principal del artículo

Claudia Liliana Valencia Granados Universidad de los Andes
Juan Camilo Vargas-Nieto Universidad de los Andes

Resumen

Resumen

El objetivo de este estudio es el de explorar la efectividad clínica de las intervenciones administradas vía internet para la depresión, a partir de la revisión sistemática de artículos de investigación con diseño de ensayo clínico aleatorizado, publicados en revistas con revisión de pares de los últimos 10 años, en inglés o español sobre tratamientos administrados vía online para la depresión. De un total de 745 referencias bibliográficas detectadas, se seleccionaron 63 artículos. El análisis sistemático de estos estudios indicó que las terapias asistidas por internet son efectivas para la reducción de síntomas de depresión. Sin embargo, son necesarios más estudios en el contexto latinoamericano teniendo en cuenta los aspectos culturales y contextuales de la población y así establecer la efectividad de esta modalidad de intervención en países de habla hispana.

Palabras clave: Terapia asistidas por internet, depresión, revisión sistemática.

Abstract

The scope of this study is to explore the clinical effectiveness of interventions conducted by the internet for treat depression. The background of the study comprises a systematic review of research articles with randomized clinical trial design published in peer-reviewed journals of the last 10 Years (both in English and Spanish) on treatments administered online for depression (of a total of 745 bibliographical references detected, 63 articles were selected). The study concludes through systematic analysis of these studies that internet-assisted therapies are truly effective in reducing symptoms of depression. However, more studies are needed at the Latin American setting (taking into account the cultural and contextual aspects of this region population), to widely establish the broad effectiveness of these kind of interventions.

Keywords: internet delivered, depression, systematic review.

Palabras clave:

Detalles del artículo

Biografía del autor/a (VER)

Claudia Liliana Valencia Granados, Universidad de los Andes

Psicóloga, Magíster en Psicología Clínica y de la Salud

Universidad de los Andes

Juan Camilo Vargas-Nieto, Universidad de los Andes

Psicóloga, Magíster en Psicología Clínica y de la Salud

Universidad de los Andes

Referencias (VER)

American Psychiatric Association (2013). Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5).

American Psychological Association (2016). Society of Clinical Psychology Division 12. Recuperado de: http://www.div12.org/psychological-treatments/disorders/depression/

Andersson, G.,Topooco, N., Havik, O. & Norgreen. T. (2015). Internet-supported versus face-to-face cognitive behavior therapy for depression. Expert Review of Neurotherapeutics, DOI: 10.1586/14737175.2015.1125783

Andersson, G., Hesser, H., Veilord, A., Svedling, L., Andersson, F., Sleman, O., Mauritzson, L., Sarkohi, A., Claesson, E., Zetterqvist, V., Lamminen, M. Eriksson, T. & Carlbring, P. (2013). Randomised controlled non-inferiority trial with 3-year follow-up of internet-delivered versus face-to-face group cognitive behavioural therapy for depression. Journal of Affective Disorders, 151(3), 986–994. http://doi.org/10.1016/j.jad.2013.08.022

Andersson, G., Sarkohi, A., Karlsson, J., Bjärehed, J.& Hesser, H. (2013). Effects of two forms of internet-delivered cognitive behaviour therapy for depression on future thinking. Cognitive Therapy and Research, 37(1), 29–34. http://doi.org/10.1007/s10608-012-9442-y

Barak, A. & Grohol, J. M. (2011). Current and Future Trends in Internet-Supported Mental Health Interventions. Journal of Technology in Human Services, 29 (3), 155-196.

Berger, T., Hämmerli, K., Gubser, N., & Caspar, F. (2011). Internet-Based Treatment of Depression : A Randomized Controlled Trial Comparing Guided with Unguided Internet-Based Treatment of Depression : A Randomized Controlled Trial Comparing Guided with Unguided Self-Help. Cognitive Behaviour Therapy, 40:4(March 2013), 37–41. http://doi.org/10.1080/16506073.2011.616531

Blackwell, S. E., Browning, M., Mathews, A., Pictet, A., Welch, J., Davies, J., Watson, P., Geddes, J. R. & Holmes, E. A. (2015). Positive imagery-based cognitive bias modification as a web-based treatment tool for depressed adults: A randomized controlled trial. Clinical Psychological Science, 3(1), 91–111. http://doi.org/10.1177/2167702614560746

Carlbring, P., Hägglund, M., Luthström, A., Dahlin, M., Kadowaki, Ä., Vernmark, K. & Andersson, G. (2013). Internet-based behavioral activation and acceptance-based treatment for depression: A randomized controlled trial. Journal of Affective Disorders, 148(2–3), 331–337. http://doi.org/10.1016/j.jad.2012.12.020

Choi, I., Zou, J., Titov, N., Dear, B. F., Li, S., Johnston, L., Andrews, G. & Hunt, C. (2012). Culturally attuned internet treatment for depression amongst Chinese Australians: A randomised controlled trial. Journal of Affective Disorders, 136(3), 459–468. http://doi.org/10.1016/j.jad.2011.11.003

Clarke, G., Kelleher, C., Hornbrook, M., Debar, L., Dickerson, J. & Gullion, C. (2009). Randomized effectiveness trial of an Internet, pure self-help, cognitive behavioral intervention for depressive symptoms in young adults. Cognitive Behaviour Therapy, 38(4), 222–34. http://doi.org/10.1080/16506070802675353

Comisión Interamericana de Derechos Humanos y Organización de los Estados Americanos. (1991). Principios para la protección de los enfermos mentales y el mejoramiento de la atención de la salud mental. Recuperado de: https://www.cidh.oas.org/PRIVADAS/principiosproteccionmental.htm

Crisp, D., Griffiths, K., Mackinnon, A., Bennett, K. & Christensen, H. (2014). An online intervention for reducing depressive symptoms: Secondary benefits for self-esteem, empowerment and quality of life. Psychiatry Research, 216(1), 60–66. http://doi.org10/.1016/j.psychres.2014.01.041

Darvell, M. J., Kavanagh, D. J. & Connolly, J. M. (2015). A qualitative exploration of Internet-based treatment for comorbid depression and alcohol misuse. Internet Interventions, 2(2), 174–182. http://doi.org/10.1016/j.invent.2015.03.003

Day, V., McGrath, P. J. & Wojtowicz, M. (2013). Internet-based guided self-help for university students with anxiety, depression and stress: A randomized controlled clinical trial. Behaviour Research and Therapy, 51(7), 344–351. http://doi.org/10.1016/j.brat.2013.03.003

Dear, B. F., Titov, N., Schwencke, G., Andrews, G., Johnston, L., Craske, M. G.& McEvoy, P. (2011). An open trial of a brief transdiagnostic internet treatment for anxiety and depression. Behaviour Research and Therapy, 49(12), 830–837. http://doi.org/10.1016/j.brat.2011.09.007

Dear, B. F., Zou, J., Titov, N., Lorian, C., Johnston, L., Spence, J., Anderson, T., Sachdev, P., Brodaty, H. & Knight, R. G. (2013). Internet-delivered cognitive behavioural therapy for depression: a feasibility open trial for older adults. The Australian and New Zealand Journal of Psychiatry, 47(2), 169–76. http://doi.org/10.1177/0004867412466154

Donker, T., Batterham, P. J., Warmerdam, L., Bennett, K., Bennett, A., Cuijpers, P., … Christensen, H. (2013). Predictors and moderators of response to internet-delivered Interpersonal Psychotherapy and Cognitive Behavior Therapy for depression. Journal of Affective Disorders, 151(1), 343–351. http://doi.org/10.1016/j.jad.2013.06.020

Donker, T., Bennett, K., Bennett, A., Mackinnon, A., Van Straten, A., Cuijpers, P., … Griffiths, K. M. (2013). Internet-delivered interpersonal psychotherapy versus internet-delivered cognitive behavioral therapy for adults with depressive symptoms: Randomized controlled noninferiority trial. Journal of Medical Internet Research. http://doi.org/10.2196/jmir.2307

Donkin, L., Hickie, I. B., Christensen, H., Naismith, S. L., Neal, B., Cockayne, N. L. & Glozier, N. (2013). Rethinking the dose-response relationship between usage and outcome in an online intervention for depression: Randomized controlled trial. Journal of Medical Internet Research. http://doi.org/10.2196/jmir.2771

Geraedts, A. S., Kleiboer, A. M., Wiezer, N. M., Cuijpers, P., van Mechelen, W. & Anema, J. R. (2014). Feasibility of a worker-directed web-based intervention for employees with depressive symptoms. Internet Interventions, 1(3), 132–140. http://doi.org/10.1016/j.invent.2014.07.001

Gervind, E., Dahlin, M. & Andersson, G. (2013). Development and initial evaluation of an Internet-based support system for face-to-face cognitive behavior therapy: a proof of concept study . Journal of Medical Internet Research . http://doi.org/http://dx.doi.org/10.2196/jmir.3031

Glozier, N., Christensen, H., Naismith, S., Cockayne, N., Donkin, L., Neal, B., Mackinnon, A. & Hickie, I. (2013). Internet-Delivered Cognitive Behavioural Therapy for Adults with Mild to Moderate Depression and High Cardiovascular Disease Risks: A Randomised Attention-Controlled Trial. PLoS ONE, 8(3), 1–8. http://doi.org/10.1371/journal.pone.0059139

Hadjistavropoulos, H. D., Pugh, N. E., Hesser, H. & Andersson, G. (2016). Predicting Response to Therapist-Assisted Internet-Delivered Cognitive Behavior Therapy for Depression or Anxiety Within an Open Dissemination Trial. Behavior Therapy, 47(2), 155–165. http://doi.org/10.1016/j.beth.2015.10.006

Hadjistavropoulos, H. D., Pugh, N. E., Nugent, M. M., Hesser, H., Andersson, G., Ivanov, M., Butz, C.G., Marchildon, G., Asmund, G. J., Klein, B. & Austin, D. W. (2014). Therapist-assisted Internet-delivered cognitive behavior therapy for depression and anxiety: Translating evidence into clinical practice. Journal of Anxiety Disorders, 28(8), 884–893. http://doi.org/10.1016/j.janxdis.2014.09.018

Hedman, E., Ljostsson, B. & Lindefors, N. (2012). Cognitive behavior therapy via the internet: A systematic review of applications, clinical efficacy and const-effectiveness. Expert Review Pharmacoeconomics Outcomes Research, 12 (6), 745- 764.

Hedman, E., Ljótsson, B., Kaldo, V., Hesser, H., El Alaoui, S., Kraepelien, M., Andersson, E., Rück, C., Svanborg, C., Andersson, G. & Lindefors, N. (2014). Effectiveness of Internet-based cognitive behaviour therapy for depression in routine psychiatric care. Journal of Affective Disorders, 155(1), 49–58. http://doi.org/10.1016/j.jad.2013.10.023

Hilvert-Bruce, Z., Rossouw, P. J., Wong, N., Sunderland, M. & Andrews, G. (2012). Adherence as a determinant of effectiveness of internet cognitive behavioural therapy for anxiety and depressive disorders. Behaviour Research and Therapy, 50(7–8), 463–468. http://doi.org/10.1016/j.brat.2012.04.001

Hoifodt, R. S., Lillevoll, K. R., Griffiths, K. M., Wilsgaard, T., Eisemann, M., Waterloo, K., & Kolstrup, N. (2013). The clinical effectiveness of web-based cognitive behavioral therapy with face-to-face therapist support for depressed primary care patients: randomized controlled trial. Journal of Medical Internet Research. http://doi.org/10.2196/jmir.2714

Hunkeler, E. M., Hargreaves, W. A, Fireman, B., Terdiman, J., Meresman, J. F., Porterfield, Y., Lee, J., Dea, R., Simon, G. E., Bauer, M. S., Unützer, J. & Taylor, C. B. (2012). A Web-Delivered Care Management and Patient Self-Management Program for Recurrent Depression: A Randomized Trial. Psychiatric Services (Washington, D.C.), 63(11), 1063–1071. http://doi.org/10.1176/appi.ps.005332011

Imamura, K., Kawakami, N., Furukawa, T. A., Matsuyama, Y., Shimazu, A., Umanodan, R., Kawakami, S. & Kasai, K. (2014). Effects of an internet-based cognitive behavioral therapy (iCBT) program in manga format on improving subthreshold depressive symptoms among healthy workers: A randomized controlled trial. PLoS ONE, 9(5). http://doi.org/10.1371/journal.pone.0097167

Johansson, R., Nyblom, A., Carlbring, P., Cuijpers, P. & Andersson, G. (2013). Choosing between Internet-based psychodynamic versus cognitive behavioral therapy for depression: a pilot preference study. BMC Psychiatry, 13(1), 268. http://doi.org/10.1186/1471-244X-13-268

Johansson, R., Sjöberg, E., Sjögren, M., Johnsson, E., Carlbring, P., Andersson, T., Rosseau, A. & Andersson, G. (2012). Tailored vs. standardized internet-based cognitive behavior therapy for depression and comorbid symptoms: a randomized controlled trial. PloS One, 7(5), e36905. http://doi.org/10.1371/journal.pone.0036905

Johnston, L., Dear, B. F., Gandy, M., Fogliati, V. J., Kayrouz, R., Sheehan, J., Rapee, R. M. & Titov, N. (2014). Exploring the efficacy and acceptability of Internet-delivered cognitive behavioural therapy for young adults with anxiety and depression: An open trial. Australian and New Zealand Journal of Psychiatry, 48(9), 819–827. http://doi.org/10.1177/0004867414527524

Junge, M. N., Lehr, D., Bockting, C. L. H., Berking, M., Riper, H., Cuijpers, P. & Ebert, D. D. (2015). For whom are internet-based occupational mental health interventions effective? Moderators of internet-based problem-solving training outcome. Internet Interventions, 2(1), 39–47. http://doi.org/10.1016/j.invent.2014.11.007

Kessler, D., Lewis, G., Kaur, S., Wiles, N., King, M., Weich, S., Sharp, D., Araya, R., Hollinghurst, S. & Peters, T. J. (2009). Therapist-delivered internet psychotherapy for depression in primary care: a randomised controlled trial. The Lancet, 374(9690), 628–634. http://doi.org/10.1016/S0140-6736(09)61257-5

Kivi, M., Eriksson, M. C. M., Hange, D., Petersson, E.-L., Vernmark, K., Johansson, B. & Björkelund, C. (2014). Internet-Based Therapy for Mild to Moderate Depression in Swedish Primary Care: Short Term Results from the PRIM-NET Randomized Controlled Trial. Cognitive Behaviour Therapy, 6073(June), 1–10. http://doi.org/10.1080/16506073.2014.921834

Kleiboer, A., Donker, T., Seekles, W., van Straten, A., Riper, H. & Cuijpers, P. (2015). A randomized controlled trial on the role of support in Internet-based problem solving therapy for depression and anxiety. Behaviour Research and Therapy, 72, 63–71. http://doi.org/10.1016/j.brat.2015.06.013

Kramer, J., Conijin, B., Oiejevaar, P. & Riper, H. (2014). Effectiveness of a web-based solution-focused brief chat treatment for depressed adolescents and young adults: Randomized controlled trial. Journal of Medical Internet Research, 16(5). http://doi:10.2196/jmir.3261

Lappalainen, P., Granlund, A., Siltanen, S., Ahonen, S., Vitikainen, M., Tolvanen, A. & Lappalainen, R. (2014). ACT Internet-based vs face-to-face? A randomized controlled trial of two ways to deliver Acceptance and Commitment Therapy for depressive symptoms: An 18-month follow-up. Behaviour Research and Therapy, 61, 43–54. http://doi.org/10.1016/j.brat.2014.07.006

Lappalainen, P., Langrial, S., Oinas-Kukkonen, H., Tolvanen, A. & Lappalainen, R. (2015). Web-based acceptance and commitment therapy for depressive symptoms with minimal support: A randomized controlled trial. Behavior Modification, 39(6), 805–834. http://doi.org/10.1177/0145445515598142

Lintvedt, O. K., Griffiths, K. M., Sorensen, K., Ostvik, A. R., Wang, C. E. A., Eisemann, M. & Waterloo, K. (2013). Evaluating the effectiveness and efficacy of unguided internet-based self-help intervention for the prevention of depression: A randomized controlled trial. Clinical Psychology and Psychotherapy, 20(1), 10–27. http://doi.org/10.1002/cpp.770

Luxton, D. D., Pruitt, L. D., O’Brien, K., Stanfill, K., Jenkins-Guarnieri, M. A., Johnson, K., Wagner, A., Thomas, E. & Gahm, G. A. (2014). Design and methodology of a randomized clinical trial of home-based telemental health treatment for U.S. military personnel and veterans with depression. Contemporary Clinical Trials, 38(1), 134–144. http://doi.org/10.1016/j.cct.2014.04.002

Ly, K.H., Topooco, N., Cederlund, H., Wallin, A., Bergström, J., Molander, O., Carlbring, P. & Andersson, G. (2015). Smartphone-Supported versus Full Behavioural Activation for Depression: A Randomised Controlled Trial. PLoS ONE 10(5): e0126559. doi:10.1371/journal.pone.0126559

Mental Health Foundation. (2016). Depression. Recuperado de https://www.mentalhealth.org.uk/a-to-z/d/depression

McCusker, J., Cole, M. G., Yaffe, M., Strumpf, E., Sewitch, M., Sussman, T., Ciampi, A., Lavoie, K., Platt, R. W. & Belzile, E. (2015). A randomized trial of a depression self-care toolkit with or without lay telephone coaching for primary care patients with chronic physical conditions. General Hospital Psychiatry, 37(3), 257–265 http://doi.org/10.1016/j.genhosppsych.2015.03.007

Mewton, L., Hobbs, M. J., Sunderland, M., Newby, J. & Andrews, G. (2014). Reductions in the internalising construct following internet-delivered treatment for anxiety and depression in primary care. Behaviour Research and Therapy, 63, 132–138. http://doi.org/10.1016/j.brat.2014.10.001

Mewton, L., Sachdev, P. S. & Andrews, G. (2013). A Naturalistic Study of the Acceptability and Effectiveness of Internet-Delivered Cognitive Behavioural Therapy for Psychiatric Disorders in Older Australians. PLoS ONE, 8(8), 1–5. http://doi.org/10.1371/journal.pone.0071825

Ministerio de Salud y Protección Social y Colciencias. (2015). Encuesta nacional de salud mental 2015. Recuperado de http://www.odc.gov.co/Portals/1/publicaciones/pdf/consumo/estudios/nacionales/CO031102015-salud_mental_tomoI.pdf

Mogoase, C., Brailean, A. & David, D. (2013). Can concreteness training alone reduce depressive symptoms? A randomized pilot study using an internet-delivered protocol. Cognitive Therapy and Research, 37(4), 704–712. http://doi.org/10.1007/s10608-012-9514-z

Moreno, F. a, Chong, J., Dumbauld, J., Humke, M. & Byreddy, S. (2012). Use of standard Webcam and Internet equipment for telepsychiatry treatment of depression among underserved Hispanics. Psychiatric Services (Washington, D.C.), 63(12), 1213–7. http://doi.org/10.1176/appi.ps.201100274

Moritz, S., Schilling, L., Hauschildt, M., Schröder, J. & Treszl, A. (2012). A randomized controlled trial of internet-based therapy in depression. Behaviour Research and Therapy, 50(7–8), 513–521. http://doi.org/10.1016/j.brat.2012.04.006

Mullin, A., Dear, B. F., Karin, E., Wootton, B. M., Staples, L. G., Johnston, L., Gandy, M., Fogliati, V. & Titov, N. (2015). The UniWellbeing course: A randomised controlled trial of a transdiagnostic internet-delivered cognitive behavioural therapy (CBT) programme for university students with symptoms of anxiety and depression. Internet Interventions, 2(2), 128–136. http://doi.org/10.1016/j.invent.2015.02.002

Nelson, C. B., Abraham, K. M., Walters, H., Pfeiffer, P. N. & Valenstein, M. (2014). Integration of peer support and computer-based CBT for veterans with depression. Computers in Human Behavior, 31(1), 57–64. http://doi.org/10.1016/j.chb.2013.10.012

Newby, J. M., Mewton, L., Williams, A. D. & Andrews, G. (2014). Effectiveness of transdiagnostic internet cognitive behavioural treatment for mixed anxiety and depression in primary care. Journal of Affective Disorders, 165, 45–52. http://doi.org/10.1016/j.jad.2014.04.037

Newby, J. M., Williams, A. D. & Andrews, G. (2014). Reductions in negative repetitive thinking and metacognitive beliefs during transdiagnostic internet cognitive behavioural therapy (iCBT) for mixed anxiety and depression. Behaviour Research and Therapy, 59, 52–60. http://doi.org/10.1016/j.brat.2014.05.009

O’Kearney, R., Kang, K., Christensen, H. & Griffiths, K. (2009). A controlled trial of a school-based internet program for reducing depressive symptoms in adolescent girls. Depression and Anxiety, 26(1), 65–72. http://doi.org/10.1002/da.20507

O’Mahen, H. A., Richards, D. A., Woodford, J., Wilkinson, E., McGinley, J., Taylor, R. S. & Warren, F. C. (2014). Netmums: a phase II randomized controlled trial of a guided Internet behavioural activation treatment for postpartum depression. Psychological Medicine, 44(8), 1675–89. http://doi.org/10.1017/S0033291713002092

O’Mahen, H. A., Woodford, J., McGinley, J., Warren, F. C., Richards, D. A., Lynch, T. R. & Taylor, R. S. (2013). Internet-based behavioral activation-Treatment for postnatal depression (Netmums): A randomized controlled trial. Journal of Affective Disorders, 150(3), 814–822. http://doi.org/10.1016/j.jad.2013.03.005

Organización Mundial de la Salud (2012). Depression: A global public health concern. Recuperado de: http://www.who.int/mental_health/management/depression/who_paper_depression_wfmh_2012.pdf

Páez, M. & Gutiérrez, O. (2002). Múltiples aplicaciones de la terapia de aceptación y compromiso. Ediciones Pirámide.

Plata, L. A., Cárdenas, G., Duran, X. & De la Rosa, A. (2014). Psicoterapia vía internet: aplicación de un programa de intervención cognitivo-conductual para pacientes con depresión. Psicología Iberoamericana, 22(1), 7-15.

Richards, D., Timulak, L., O’Brien, E., Hayes, C., Vigano, N., Sharry, J. & Doherty, G. (2015). A randomized controlled trial of an internet-delivered treatment: Its potential as a low-intensity community intervention for adults with symptoms of depression. Behaviour Research and Therapy, 75, 20–31. http://doi.org/10.1016/j.brat.2015.10.005

Richards, D. & Richardson, T. (2012). Computer-based psychological treatments for depression: A systematic review and meta-analysis. Clinical Psychology Review, doi: 10.1016/j.cpr.2012.02.004

Robinson, J., Hetrick, S., Cox, G., Bendall, S., Yuen, H. P., Yung, A. & Pirkis, J. (2016). Can an Internet-based intervention reduce suicidal ideation, depression and hopelessness among secondary school students: Results from a pilot study. Early Intervention in Psychiatry, 10(1), 28–35. http://doi.org/10.1111/eip.12137

Rochlen, A. B., Zack, J. S. & Speyer, C. (2004). Online therapy: review of relevant definitions, debates, and current empirical support. Journal of Clinical Psychology, 60 (3), 269-283.

Schueller, S. M. & Parks, A. C. (2012). Disseminating self-help: Positive psychology exercises in an online trial. Journal of Medical Internet Research. http://doi.org/10.2196/jmir.1850

Sharry, J., Davidson, R., McLoughlin, O. & Doherty, G. (2013). A service-based evaluation of a therapist-supported online cognitive behavioral therapy program for depression. Journal of Medical Internet Research. http://doi.org/10.2196/jmir.2248

Sheeber, L. B., Seeley, J. R., Feil, E. G., Davis, B., Sorensen, E., Kosty, D. B., & Lewinsohn, P. M. (2012). Development and pilot evaluation of an Internet-facilitated cognitive-behavioral intervention for maternal depression. Journal of Consulting and Clinical Psychology, 80(5), 739–49. http://doi.org/10.1037/a0028820

Titov, N., Dear, B. F., Ali, S., Zou, J. B., Lorian, C. N., Johnston, L., Terides, M. D., Kayrouz, R., Klein, B. Gandy, M. & Fogliati, V. J. (2015). Clinical and Cost-Effectiveness of Therapist-Guided Internet-Delivered Cognitive Behavior Therapy for Older Adults With Symptoms of Depression: A Randomized Controlled Trial. Behavior Therapy, 46(2), 193–205. http://doi.org/10.1016/j.beth.2014.09.008

Titov, N., Dear, B. F., Schwencke, G., Andrews, G., Johnston, L., Craske, M. G. & McEvoy, P. (2011). Transdiagnostic internet treatment for anxiety and depression: A randomised controlled trial. Behaviour Research and Therapy, 49(8), 441–452. http://doi.org/10.1016/j.brat.2011.03.007

Titov, N., Dear, B. F., Johnston, L., Lorian, C., Zou, J., Wootton, B., Spence, J., McEvoy, P. M. & Rapee, R. M. (2013). Improving Adherence and Clinical Outcomes in Self-Guided Internet Treatment for Anxiety and Depression: Randomised Controlled Trial. PLoS ONE, 8(7). http://doi.org/10.1371/journal.pone.0062873

Vernmark, K., Lenndin, J., Bjärehed, J., Carlsson, M., Karlsson, J., Öberg, J., Carlbring, P., Eriksson, T. & Andersson, G. (2010). Internet administered guided self-help versus individualized e-mail therapy: A randomized trial of two versions of CBT for major depression. Behaviour Research and Therapy, 48(5), 368–376. http://doi.org/10.1016/j.brat.2010.01.005

Wagner, B., Horn, A. B. & Maercker, A. (2014) Internet-based versus face-to-face cognitive-behavioral intervention for depression: a randomized controlled non-inferiority trial. Journal of Affective Disorders, 113-121. http://dx.doi.org/10.1016/j.jad.2013.06.032

Williams, A. D., Blackwell, S. E., Mackenzie, A., Holmes, E. A., & Andrews, G. (2013). Combining Imagination and Reason in the Treatment of Depression: A Randomized Controlled Trial of Internet-Based Cognitive-Bias Modification and Internet-CBT for depression. Journal of Consulting and Clinical Psychology, 81(5), 793–9. http://doi.org/10.1037/a0033247

Wong, N., Kady, L., Mewton, L., Sunderland, M., & Andrews, G. (2014). Preventing anxiety and depression in adolescents: A randomised controlled trial of two school based Internet-delivered cognitive behavioural therapy programmes. Internet Interventions, 1(2), 90–94. http://doi.org/10.1016/j.invent.2014.05.004

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